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KMID : 0391520180260040205
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Journal of the Korean Child Neurology Society
2018 Volume.26 No. 4 p.205 ~ p.209
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Association of Low Serum Ionized Magnesium Level with Fever-Triggered Seizures in Epileptic Children
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Suh Sunny
Kim Kyung-Ju
Byeon Jung-Hye
Eun So-Hee
Eun Baik-Lin
Kim Gun-Ha
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Abstract
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Purpose: Several studies have shown that magnesium plays an important role in modulating N-methyl-D-aspartate (NMDA)-related seizures by blocking NMDA ion channel receptors. Clinicians usually measure total serum magnesium levels instead of biologically active ionized magnesium levels. We compared the serum ionized magnesium (iMg2+) level between epileptic children with and without a history of fever-triggered seizure (FTS).
Methods: All epileptic children who visited the outpatient clinic or pediatric emergency department at Korea University Guro Hospital between January 2015 and July 2017 were included. Only epileptic children aged 1-8 years who were newly diagnosed within 2 years were included.
Results: There were 12 children with FTS and 16 without FTS. Median serum iMg2+ level was 0.93 (0.85-1.14, quartile) mEq/L. Serum iMg2+ level was significantly lower in epileptic children with FTS (0.86 mEq/L) compared to those without FTS (1.10 mEq/L) (P =0.005). No difference was noted in clinical variables between the two groups. Lower serum iMg2+ level significantly increased the risk of having FTS in epileptic children based on multivariable logistic regression analysis (odds ratio [OR]=0.028).
Conclusion: Serum iMg2+ level was significantly lower in epileptic children with FTS than in those without FTS. Measurement of biologically active serum iMg2+ level could be considered in epileptic children with recurrent FTS. A large-scale prospective study is warranted.
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KEYWORD
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Epilepsy, Magnesium, Febrile convulsion, Child
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